A role for YY1 in sex-biased transcription revealed through X-linked promoter activity and allelic binding analyses
نویسندگان
چکیده
1 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada 2 Graduate Program in Bioinformatics, University of British Columbia, Vancouver, British Columbia, Canada 3 RIKEN Omics Science Center, Yokohama, Japan 4 RIKEN Center for Life Science Technologies, Division of Genomic Technologies, Yokohama, Japan 5 RIKEN Preventive Medicine and Diagnosis Innovation Program, Wako, Saitama, Japan 6 Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
منابع مشابه
YY1 binding association with sex-biased transcription revealed through X-linked transcript levels and allelic binding analyses
Sex differences in susceptibility and progression have been reported in numerous diseases. Female cells have two copies of the X chromosome with X-chromosome inactivation imparting mono-allelic gene silencing for dosage compensation. However, a subset of genes, named escapees, escape silencing and are transcribed bi-allelically resulting in sexual dimorphism. Here we conducted in silico analyse...
متن کاملOverlapping YY1- and aberrant SP1-binding sites proximal to the early promoter of human papillomavirus type 16.
Transcription of oncogenes E6 and E7 of human papillomavirus type 16 (HPV-16) from the P97 promoter is regulated by viral and cellular proteins. The transcription factor YY1 represses transcription through binding to cognate sequences in the long control region (LCR). In HPV-16 DNA from cervical carcinomas, mutations of YY1-binding sites have been identified that increase P97 activity 3-6-fold....
متن کاملDNA bending and orientation-dependent function of YY1 in the c-fos promoter.
The assembly of multicomponent complexes at promoters, enhancers, and silencers likely entails perturbations in the path of the DNA helix. We present evidence that YY1, a ubiquitously expressed DNA-binding protein, regulates the activity of the c-fos promoter primarily through an effect on DNA structure. YY1 binds to and induces a phased DNA bend at three sites in this promoter. By use of a tru...
متن کاملIdentification of clustered YY1 binding sites in imprinting control regions.
Mammalian genomic imprinting is regulated by imprinting control regions (ICRs) that are usually associated with tandem arrays of transcription factor binding sites. In this study, the sequence features derived from a tandem array of YY1 binding sites of Peg3-DMR (differentially methylated region) led us to identify three additional clustered YY1 binding sites, which are also localized within th...
متن کاملCompetitive binding between Seryl-tRNA synthetase/YY1 complex and NFKB1 at the distal segment results in differential regulation of human vegfa promoter activity during angiogenesis
Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis. Previous studies focused on transcriptional regulation modulated by proximal upstream cis-regulatory elements (CREs) of the human vegfa promoter. However, we hypothesized that distal upstream CREs may also be involved in controlling vegfa transcription. In this study, we found that the catalytic domain of Seryl-tRNA...
متن کامل